We assessed edge avoidance, area sensitivity, and the relationship between local and regional forest cover for nesting Red-eyed Vireos (Vireo olivaceus) in 13 forest fragments (1–2,353 ha in size) in southcentral Ontario, Canada. Red-eyed Vireo territories and nests were not significantly farther from the edge than random points in any of the forest fragments, and there was no relationship between the probability of a male pairing and the distance of the territory from the edge of the forest fragment. The density of singing males and the probability of a male being paired increased significantly with increasing local forest cover within a 2-km radius of a study site, but not with forest fragment area or regional forest cover within a 10-km radius. Nest success was low and the probability of a nest being parasitized by the Brown-headed Cowbird (Molothrus ater) or successfully fledging ≥1 host young did not vary with distance of the nest from the forest edge or with any of our area or forest cover measures. Red-eyed Vireos did not display edge avoidance nor did they appear to be area sensitive within our study region, but there was a positive relationship with the amount of local (2-km radius) forest cover. Maintaining localized regions with high forest cover has been recommended on numerous occasions for the conservation of area sensitive species; our results suggest high forest cover also may benefit species that do not appear to be area sensitive.